Mouthwash Use May Increase Your Risk for Developing Hypertension, Diabetes and Stroke 

                            

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If your mouthwash contains the antibacterial chlorhexidine, you may be increasing your risk for developing hypertension, stroke and diabetes (by reducing the "good bacteria" (good flora) in your mouth that help create a very beneficial neurotransmitter known as nitric oxide (excellent podcast about the benefits of nitric oxide)).  Note: Nitric Oxide relaxes our arteries to help maintain optimal blood circulation/blood pressure levels in our bodies, prevents blood clots, helps maintain our metabolism and also improves insulin sensitivity (among many other things in our bodies involving supporting our immune system, memory and learning).  Thus, if you reduce nitric oxide levels in your body (by using chlorhexidine containing mouthwashes), this could increase your risks for developing high blood pressure, stroke and diabetes. 

Bottom line: If you do not have a specific dental condition (i.e. severe gingivitis) that requires the medical use of chlorhexidine containing mouthwashes, then try to avoid them. Also, be aware that other mouthwashes may also contain other kinds of antibacterial agents that may disrupt levels of "good bacteria" in your mouth as well.

Antiseptic mouthwash treatment reduced oral nitrite production by 90% (p < 0.001) and plasma nitrite levels by 25% (p = 0.001) compared to the control period. Systolic and diastolic blood pressure increased by 2–3.5 mm Hg, increases correlated to a decrease in circulating nitrite concentrations (r² = 0.56, p = 0.002).Antiseptic mouthwash use abrogates oral bacterial conversion of nitrate to nitrite.         

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References:

The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash.

Your Antibacterial Mouthwash Might Be Slowly Killing You

A stepwise reduction in plasma and salivary nitrite with increasing strengths of mouthwash following a dietary nitrate load.

Physiological role for nitrate-reducing oral bacteria in blood pressure control 

Nitric Oxide and Cardiac Function

Mouthwash may kill beneficial bacteria in mouth and trigger diabetes, Harvard study suggests

Over-the-counter mouthwash use and risk of pre-diabetes/diabetes

Mouthwashes 'can raise risk of heart attack and strokes': Antiseptic gargles kill good bacteria that help keep blood pressure down

NITRIC OXIDE AND DIABETES 

Nitric Oxide Increases Insulin Sensitivity in Skeletal Muscle by Improving Mitochondrial Function and Insulin Signaling